Search results for "target [nucleus]"

showing 10 items of 78 documents

Social Influence Maximization in Hypergraphs

2021

This work deals with a generalization of the minimum Target Set Selection (TSS) problem, a key algorithmic question in information diffusion research due to its potential commercial value. Firstly proposed by Kempe et al., the TSS problem is based on a linear threshold diffusion model defined on an input graph with node thresholds, quantifying the hardness to influence each node. The goal is to find the smaller set of items that can influence the whole network according to the diffusion model defined. This study generalizes the TSS problem on networks characterized by many-to-many relationships modeled via hypergraphs. Specifically, we introduce a linear threshold diffusion process on such …

Hypergraphsocial networksSelection (relational algebra)Computer scienceGeneralizationScienceQC1-999hypergraphGeneral Physics and Astronomy02 engineering and technologyAstrophysicsArticlehigh-order networkSet (abstract data type)influence diffusion020204 information systems0202 electrical engineering electronic engineering information engineeringDiscrete mathematicshigh-order networks; hypergraphs; influence diffusion; social networks; target set selectionPhysicsQMaximizationQB460-466high-order networkshypergraphstarget set selectionGraph (abstract data type)020201 artificial intelligence & image processingNode (circuits)Heuristics
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Concurrent TMS-fMRI for causal network perturbation and proof of target engagement

2021

The experimental manipulation of neural activity by neurostimulation techniques overcomes the inherent limitations of correlative recordings, enabling the researcher to investigate causal brain-behavior relationships. But only when stimulation and recordings are combined, the direct impact of the stimulation on neural activity can be evaluated. In humans, this can be achieved non-invasively through the concurrent combination of transcranial magnetic stimulation (TMS) with functional magnetic resonance imaging (fMRI). Concurrent TMS-fMRI allows the assessment of the neurovascular responses evoked by TMS with excellent spatial resolution and full-brain coverage. This enables the functional ma…

Interleavedgenetic structuresComputer scienceCognitive Neurosciencemedicine.medical_treatmentNeurosciences. Biological psychiatry. NeuropsychiatryReviewbehavioral disciplines and activities050105 experimental psychologyTask (project management)03 medical and health sciencesNeural activity0302 clinical medicineTranscranial magnetic stimulation (TMS)medicineHumans0501 psychology and cognitive sciencesNeurostimulationTranscranial magnetic stimulation (TMS) ; Concurrent ; Simultaneous ; Functional magnetic resonance imaging (fMRI) ; Review ; InterleavedBrain MappingArtificial neural networkmedicine.diagnostic_test05 social sciencesTarget engagementMagnetic Resonance ImagingTranscranial Magnetic StimulationConcurrentTranscranial magnetic stimulationFunctional magnetic resonance imaging (fMRI)Functional mappingNeurologynervous systemNeurovascular CouplingNerve NetFunctional magnetic resonance imagingNeuroscienceSimultaneous030217 neurology & neurosurgerypsychological phenomena and processesRC321-571
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Implementare le politiche sanitarie a livello regionale per l'eliminazione dell'epatite C ai tempi del COVID-19

2022

Viral hepatitis C is an important public health problem and its elimination by 2030, defined by the World Health Organization, is an ambitious goal. The chance of free screening for HCV infection represents an important achievement that requires a successful State-Regions coordination and an effective regional organisation, that guarantees an interdisciplinary course between local and specialized healthcare. A structured communication program to increase the sensitivity of target populations as well as health professionals is the key for success. The implementation of the proactive screening, defined by the Milleproroghe Law, is crucial because it will define the tracks for the whole HCV co…

L'epatite virale C (HCV) è un importante problema di salute pubblica e la sua eliminazione entro il 2030 indicata come target dall’Organizzazione Mondiale della Sanità è un obiettivo ambizioso. L’offerta di screening gratuito per l’infezione da HCV è un importante traguardo che richiede un proficuo coordinamento Stato-Regioni e un’efficace organizzazione regionale che garantisca un percorso interdisciplinare tra medicina del territorio e specialistica. Un programma di comunicazione per la sensibilizzazione delle popolazioni target e degli operatori sanitari è la chiave principale del successo. L'implementazione dello screening proattivo (come definito dalla Legge Milleproroghe) è il primo passo nella realizzazione dell'intero screening (tutta la coorte di nascita tra 1948-1988) ritenuta la strategia più costo-efficace necessaria per raggiungere in Italia gli obiettivi di eliminazione dell'HCV entro il 2030.
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Early and midterm outcomes of bioresorbable vascular scaffolds for ostial coronary lesions: insights from the GHOST-EU registry.

2016

Aims: We aimed to investigate the outcomes of bioresorbable vascular scaffolds (BVS) in coronary ostial lesions. Ostial lesions represent a challenging angiographic subset, with higher event rates compared with non-ostial lesions. BVS might be associated with advantages over the long term, but their safety in this setting remains to be explored. Methods and results: Procedural and 12-month follow-up data from consecutive patients treated with BVS for lesions located at the ostium of the right (RCA), left anterior (LAD) or circumflex (LCX) coronary in 11 European centres were collected. The primary device-oriented endpoint was defined as a combination of cardiovascular death, target vessel m…

LCX (29Target lesionMale52%). Patients presenting with ostial lesions did not differ from the remaining cohort except for a higher incidence of prior revascularisation. Predilation was performed in 97% of the lesions (vs. 96% in non-ostialp= 0.035)medicine.medical_treatmentMyocardial Infarction304 patients with a mean age of 62 +/- 11years. There were 90 ostial lesions (5.8%) in 84 patients (6.4%) located at the ostial RCA (14Coronary Artery Disease030204 cardiovascular system & hematologyCoronary artery diseasebut their safety in this setting remains to be explored. Methods and results: Procedural and 12-month follow-up data from consecutive patients treated with BVS for lesions located at the ostium of the right (RCA)0302 clinical medicineAbsorbable Implants030212 general & internal medicineMyocardial infarctionCircumflexRegistriesTissue Scaffolds32%)Drug-Eluting StentsMiddle AgedThrombosisCoronary VesselsAims: We aimed to investigate the outcomes of bioresorbable vascular scaffolds (BVS) in coronary ostial lesions. Ostial lesions represent a challenging angiographic subset with higher event rates compared with non-ostial lesions. BVS might be associated with advantages over the long term but their safety in this setting remains to be explored. Methods and results: Procedural and 12-month follow-up data from consecutive patients treated with BVS for lesions located at the ostium of the right (RCA) left anterior (LAD) or circumflex (LCX) coronary in 11 European centres were collected. The primary device-oriented endpoint was defined as a combination of cardiovascular death target vessel myocardial infarction or target lesion revascularisation. The database included a total of 1549 lesions in 1304 patients with a mean age of 62 +/- 11years. There were 90 ostial lesions (5.8%) in 84 patients (6.4%) located at the ostial RCA (14; 16%) LCX (29; 32%) or LAD (47; 52%). Patients presenting with ostial lesions did not differ from the remaining cohort except for a higher incidence of prior revascularisation. Predilation was performed in 97% of the lesions (vs. 96% in non-ostial p= 0.618) post-dilation in 43% (versus 58% in the non-ostial group p= 0.008). At quantitative coronary angiography treatment of ostial lesions was associated with higher residual stenosis (30% [23-41] vs. 26% [20-37] p= 0.035) but no difference in minimum lumen diameter existed (p= 0.447). Follow-up data were available at 385 [362-465] days. The 12-month Kaplan-Meier estimated rates of scaffold thrombosis were 4.9% and 2.0% (ostial and non-ostial lesion groups respectively log-rank p= 0.005). The device-oriented composite endpoint occurred respectively in 12.6% and 4.6% at 12 months (log-rank p= 0.001). Treatment of ostial lesions was an independent predictor of this endpoint (p= 0.0025 HR 2.65 [1.41-4.97]).OstiumAims: We aimed to investigate the outcomes of bioresorbable vascular scaffolds (BVS) in coronary ostial lesions. Ostial lesions represent a challenging angiographic subsetTreatment Outcomein 12.6% and 4.6% at 12 months (log-rank p= 0.001). Treatment of ostial lesions was an independent predictor of this endpoint (p= 0.0025CardiologyFemale549 lesions in 1medicine.symptomCardiology and Cardiovascular MedicineAdultpost-dilation in 43% (versus 58% in the non-ostial groupmedicine.medical_specialtyor LAD (47HR 2.65 [1.41-4.97])but no difference in minimum lumen diameter existed (p= 0.447). Follow-up data were available at 385 [362-465] days. The 12-month Kaplan-Meier estimated rates of scaffold thrombosis were 4.9% and 2.0% (ostial and non-ostial lesion groupsrespectivelyLesion03 medical and health sciencesPercutaneous Coronary Interventionwith higher event rates compared with non-ostial lesions. BVS might be associated with advantages over the long termleft anterior (LAD) or circumflex (LCX) coronary in 11 European centres were collected. The primary device-oriented endpoint was defined as a combination of cardiovascular deathInternal medicinemedicineHumanstarget vessel myocardial infarction or target lesion revascularisation. The database included a total of 1Agedp= 0.008). At quantitative coronary angiographybusiness.industryPercutaneous coronary interventionp= 0.618)treatment of ostial lesions was associated with higher residual stenosis (30% [23-41] vs. 26% [20-37]log-rank p= 0.005). The device-oriented composite endpoint occurredmedicine.diseaseSurgery16%)businessEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
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DISCOURSE INTERFERENCE IN TRANSLATION

2001

This article focuses on three major factors that may enhance the degree of hybridity of target texts: first, the ideological background, i.e., the prestige accorded to the source culture in relation to the target culture; second, translator's competence, i.e., the translator's ability to rationalise translation process and choose an adequate translation strategy; third, the skopos of translation, i.e., hybrid features may be deliberately imposed upon the translation to enable the text to serve a given function. Each of these factors is analysed within a framework of a concrete text. The conclusion of this analysis is that due to the functionalist approach, the concept of translation has bec…

Linguistics and LanguageHybridityTarget cultureComputer sciencemedia_common.quotation_subjectPrestigeIdeologySource textCompetence (human resources)Language and LinguisticsDynamic and formal equivalenceLinguisticsmedia_commonAcross Languages and Cultures
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Learning a class of regular expressions via restricted subset queries

1992

A wide class of regular expressions non-representable as unions of “smaller” expressions is shown to be polynomial-time learnable via restricted subset queries from arbitrary representative examples “reflecting” the loop structure and a way the input example is obtained from the unknown expression. The corresponding subclass of regular expressions of loop depth at most 1 is shown to be learnable from representative examples via membership queries. A wide class of expressions with loops A+ of arbitrary loop depth is shown to be learnable via restricted subset queries from arbitrary examples.

Loop (topology)CombinatoricsDiscrete mathematicsClass (set theory)Regular languageStructure (category theory)Regular expressionSubclassExpression (mathematics)MathematicsTarget expression
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Hepatocellular carcinoma enhancement on contrast-enhanced CT and MR imaging: response assessment after treatment with sorafenib: preliminary results

2012

PURPOSE: This study was undertaken to compare response evaluation criteria in solid tumours (RECIST) 1.1 and modified RECIST (mRECIST) in patients with unresectable hepatocellular carcinoma (HCC) on sorafenib, and to describe HCC enhancement changes before and after sorafenib treatment. METHODS AND MATERIALS: Seventeen patients (12 men, 5 women; mean age 69 years; age range 58-79 years) were included. Tumour response was assessed according to RECIST and mRECIST. Two readers placed a region of interest (ROI) within each target lesion, on the portion showing enhancement during the arterial phase. The lesion attenuation values measured within the ROIs on computed tomography or the signal inten…

MaleNiacinamideSorafenibTarget lesionmedicine.medical_specialtyCarcinoma HepatocellularContrast MediaMeglumineOrganometallic CompoundsCarcinomamedicineHumansRadiology Nuclear Medicine and imagingAgedNeuroradiologymedicine.diagnostic_testbusiness.industryPhenylurea CompoundsLiver NeoplasmsLiver CT MR HCC SorafenibMagnetic resonance imagingGeneral MedicineMiddle AgedSorafenibmedicine.diseaseMagnetic Resonance ImagingIopamidolTreatment OutcomeHepatocellular carcinomaMann–Whitney U testFemaleRadiologyTomography X-Ray ComputedbusinessProgressive diseasemedicine.drugLa radiologia medica
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Percutaneous coronary intervention with everolimus-eluting bioresorbable vascular scaffolds in routine clinical practice: early and midterm outcomes …

2015

Clinical data on the early and midterm outcomes of bioresorbable vascular scaffolds (BVS) in routine clinical practice are limited. To fill this gap, we report on the early and midterm clinical outcomes of PCI with everolimus-eluting BVS from the large multicentre GHOST-EU registry.Between November 2011 and January 2014, 1,189 patients underwent percutaneous coronary intervention with one or more BVS (Absorb BVS; Abbott Vascular, Santa Clara, CA, USA) at 10 European centres. The primary outcome of interest was target lesion failure (TLF), defined as the combination of cardiac death, target vessel myocardial infarction, or clinically driven target lesion revascularisation (TLR). A total of 1…

MaleReoperationTarget lesionmedicine.medical_specialtymedicine.medical_treatmentMyocardial InfarctionAntineoplastic AgentsComorbidityCoronary Artery DiseaseAngina PectorisPercutaneous Coronary InterventionRisk FactorsInterquartile rangeInternal medicineAbsorbable ImplantsDiabetes MellitusmedicineHumansCumulative incidenceEverolimusMyocardial infarctionAcute Coronary SyndromeAgedProportional Hazards ModelsTissue Scaffoldsbusiness.industryHazard ratioPercutaneous coronary interventionDrug-Eluting StentsThrombosisMiddle Agedmedicine.diseaseThrombosisSurgeryEuropeTreatment OutcomeCardiovascular DiseasesConventional PCICardiologyFemaleCardiology and Cardiovascular MedicinebusinessEuroIntervention
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Five-Year Results of the Bioflow-III Registry:Real-World Experience with a Biodegradable Polymer Sirolimus-Eluting Stent

2018

Abstract Purpose We aimed to assess long-term safety and performance of the Orsiro sirolimus-eluting coronary stent with biodegradable polymer in a large unselected population and in pre-specified subgroups. Methods BIOFLOW-III is a prospective, multicenter, international, observational registry with follow-up visits scheduled at 6 and 12 months, and at 3 and 5 years ( NCT01553526 ). Results 1356 patients with 1738 lesions were enrolled. Of those, 392 (28.9%) declined to participate in the study extension from 18 months to 5 years, 37 (2.7%) withdrew consent, and 89 (6.6%) were lost to follow-up. At 5-years, Kaplan-Meier estimates of target lesion failure, defined as a composite of cardiac …

MaleTarget lesionTime Factorsmedicine.medical_treatmentMyocardial InfarctionCoronary Artery Disease030204 cardiovascular system & hematology0302 clinical medicineRecurrenceRisk FactorsAbsorbable ImplantsBiodegradable polymerProspective StudiesRegistries030212 general & internal medicineMyocardial infarctionAngioplasty Balloon Coronaryeducation.field_of_studyDiabetesDrug-Eluting StentsGeneral MedicineCoronary artery stenosisMiddle AgedTreatment OutcomeDrug-eluting stentFemaleCardiology and Cardiovascular Medicinemedicine.medical_specialtyPolyestersPopulationHybrid stentProsthesis Design03 medical and health sciencesDiabetes mellitusCoronary stentmedicineHumanseducationAgedSirolimusbusiness.industryCoronary ThrombosisStentCardiovascular Agentsmedicine.diseaseConfidence intervalSurgeryCoronary OcclusionChronic DiseaseDrug-eluting stentbusiness
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Long-term follow-up after drug eluting stent implantation in left main trifurcations

2009

Aims: Trifurcation lesions, which are mostly observed in distal left main (LM), represent a technical challenge for interventional cardiologists. We sought to determine the feasibility and long-term clinical outcome of drug eluting stent (DES) implantation in patients with LM coronary trifurcation lesions. Methods and results: All patients with clinically significant de novo LM trifurcation lesions, who refused coronary artery bypass surgery and were considered eligible for percutaneous coronary intervention (PCI), were consecutively enrolled in this study from November 2005 to February 2007. Eleven patients (65±9 years, 91% men) met all the inclusion criteria and underwent LM trifurcation …

MaleTarget lesionmedicine.medical_specialtyPaclitaxelmedicine.medical_treatmentTrifurcation lesions.Coronary DiseaseCoronary AngiographyCoronary artery bypass surgeryClinical endpointStentHumansMedicineMyocardial infarctionAgedSirolimusbusiness.industryAngioplastyStentPercutaneous coronary interventionDrug-Eluting StentsEquipment DesignMiddle Agedmedicine.diseaseCoronary VesselsDESTubulin ModulatorsSurgeryDrug-eluting stentConventional PCIFemaleRadiologyCardiology and Cardiovascular MedicinebusinessImmunosuppressive AgentsFollow-Up Studies
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